(B) Spleen

The organ primarily affected by malaria is the spleen. Malaria is a parasitic infection caused by Plasmodium parasites that are transmitted through the bites of infected mosquitoes. The parasites multiply in the liver and then infect red blood cells, leading to symptoms such as fever, chills, and an enlarged spleen. The spleen plays a crucial role in the immune response against malaria, but the infection can cause it to enlarge as it filters out infected red blood cells from the circulation. If left untreated, severe cases of malaria can lead to complications, including damage to the spleen and other organs.